ABSTRACT
To study the CT-scan changes in brain in patients of tuberculous meningitis and their correlation with stage of disease and its outcome.A prospective, hospital - based, clinico - radiological study of one year duration including 48 pediatric and 44 adult patients. 50% of patients in the stage I had normal CT-Scan and this proportion decreased to 10.53% in stage - II and 6.67% in stage III. A normal CT-scan is associated with complete recovery in 72.22%, partial recovery in 16.67% and death in 11.11% of cases. Abnormal CTscan is associated with advancing stages of disease and a poor outcome. CT-scan is a valuable tool for diagnosis and monitoring the progress of cases of tuberculous meningitis.
Subject(s)
Animals , Carbamazepine/pharmacology , Digoxin/pharmacology , Dogs , Drug Interactions , Electrocardiography , Female , Heart/drug effects , MaleSubject(s)
Adolescent , Adult , Age Factors , Aged , Alcohol Drinking , Data Collection , Female , Humans , India , Male , Middle Aged , Rural Population , Sex FactorsSubject(s)
Animals , Disease Models, Animal , Female , Gastric Juice/drug effects , Male , Phenothiazines/pharmacology , Rats , Stomach Ulcer/drug therapySubject(s)
Adolescent , Adult , Age Factors , Humans , India , Male , Rural Population , Substance-Related Disorders/epidemiologyABSTRACT
Fenitrothion (Sumithion), and organophosphorous insectide, was applied dermally to rats. Cholinesterase activity was measured in blood and brain. The concentration of the pesticide in blood plasma and acetylcholine in brain were estimated at different intervals. The maximum concentration of Fenitrothion in the plasma was found at 4 hrs while significantly elevated levels of acetylcholine were present in the brain till 24 hrs. The results suggest that the compound was readily absorbed by dermal route to produce inhibition of cholinesterase and a consequent persistent increase in brain acetylcholine.